New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization

Article history: Received on: 11/06/2013 Revised on: 29/06/2013 Accepted on: 11/07/2013 Available online: 30/07/2013 Three new chalcogenic thiosemicarbazones (3,4-difluoroacetophenone thiosemicarbazone(1), 2-bromo-4’chloroacetophenone thiosemicarbazone(2) and 2, 4’-dibromoacetophenone thiosemicarbazone(3) are synthesized by using a conventional one step processes in which the respective halo-substituted acetophenones are condensed with thiosemicarbazide to result in the formation of the product. The chalcogenic thiosemicarbazones are then characterized by the spectroscopic techniques like FT-IR, FT-Raman, UV-Vis, H and C NMR (F for 1), HRMS and LC-MS, TG-DTA. The compound 1 is unambiguously characterized by single crystal X-ray diffraction and is found to have monoclinic system. These compounds were further tested for their antimicrobial activity against some human pathogens like E. coli, B. subtilis, P. aureginosa and S. aureus. The MIC values have suggested that these are potential antimicrobial agents.